Double Versus Single Dose Methotrexate Regimens in Management of Undisturbed Ectopic Pregnancy
نویسنده
چکیده
Methods: A prospective randomized-controlled trial was conducted on 200 patients with ectopic pregnancy at the Obstetrics and gynecological Departments of Zagazig University, Egypt between June, 20 11 to May 2014. Patients were randomized into two groups, (group 1) who received a single dose 50 mg per meters squared surface area methotrexate (50 mg/m2 IM on day 1) intramuscularly or (group 2), who received double-dose methotrexate regimen (50 mg/m2 intramuscularly on days 1 and 4). The outcomes were; success rate, time duration of fall down of b-hcg to < 15 mlU/mL and undesirable effects of methotrexate.
منابع مشابه
مقایسه اثر درمانی تجویز متوترکسات تک دوز با دو دوز در درمان حاملگی خارج رحمی
Background & Aims: Ectopic pregnancy currently is the leading cause of pregnancy-related death during the first trimester. The methotrexate (MTX) was accepted as medical treatment and reduced surgery in unruptured ectopic pregnancy. Despite numerous studies, the best protocol for MTX treatment remains controversial. The present study compares single and two dose MTX administrations protocol in ...
متن کاملEffect of Single-Dose Methotrexate Treatment on Ovarian Reserve in Women with Ectopic Pregnancy Undergoing Infertility Treatment: A Single-Center Experience
Background: The aim of this study was evaluation of the impact of single-dose methotrexate (MTX) treatment on ovarian reserve in women with ectopic pregnancy (EP) undergoing infertility treatment in Iranian population. Materials and Methods: This prospective cohort study was done between March 2015 and March 2017 in Tehran General Women Hospital, Tehran, Iran. We enrolled 20 patients with EP wh...
متن کاملComparision of Single and Multidose of Methotrexate in Medical Treatment of Ectopic Pregnancy
Objective: The purpose of this study was to compare the efficacy and safety of two regimens of methotrexate for medical treatment of ectopic pregnancy. Methodology: In this prospective randomized clinical trial 100 women clinically suspected to have un ruptured ectopic pregnancy were randomly (One by one) treated with single (50mg/m2) and multi dose (1mg/kg MTX+ 0.1mg/kg folinic acid) Methotrex...
متن کاملThe medical management of ectopic pregnancy: a meta-analysis comparing "single dose" and "multidose" regimens.
OBJECTIVE Medical management of an unruptured ectopic pregnancy with intramuscular methotrexate is common and cost-effective. Two treatment protocols, the "single dose" and the "multidose," have been advocated and independently reported in the medical literature. This analysis systematically compares the success and prevalence of side effects of these two regimens. DATA SOURCES Published data...
متن کاملComparison of Two Different Protocols of Methotrexate Therapy in Medical Management of Ectopic Pregnancy
BACKGROUND Ectopic pregnancy (EP) is one of the most dangerous complications of pregnancy and without prompt diagnosis and treatment, it could become a major cause of maternal morbidity and mortality. OBJECTIVES In this randomized controlled study, we compared single and double dose of methotrexate (MTX) therapy in the treatment of ectopic pregnancy. PATIENTS AND METHODS This study was perf...
متن کامل